Anal human papillomavirus infection among HIV-infected men in Korea

Chang Hun Lee, Sun Hee Lee, Shinwon Lee, Heerim Cho, Kye Hyung Kim, Jung Eun Lee, Eun Ju Jung, Su Jin Lee, Eun Jung Kim, Ki Hyung Kim, Eunsoo Moon, Hong Je Cho

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12 Scopus citations

Abstract

Background: Little is known about the epidemiology on human papillomavirus (HPV) infection among HIV-infected men in Korea. The objective of this study was to determine the prevalence, genotype distribution and risk factors associated with anal HPV infection among HIV-infected men in Korea. Methods: A single-center cross-sectional study was conducted with HIV-infected men in Korea. Participants completed a detailed sexual behavior risk factor questionnaire. Anal samples were collected for cytology and HPV genotyping. Factors associated with anal HPV infection were assessed using multivariable logistic regression, stratifying by sexual behaviour. Results: A total of 201 HIV-infected men were included in the study: 133 were from men who have sex with men (MSM) and 68 from men who have sex with women (MSW). Any anal HPV infection was detected in 82.7% of HIV-infected MSM and in 51.5% of HIV-infected MSW (P < 0.001). High-risk HPV (HR-HPV) prevalence was higher among MSM (47.4%) than MSW (25.0%; P = 0.002). The HR-HPV types identified most frequently were HPV 16 (11%), HPV 18 (9.9%), and HPV 58 (5%) in MSM, and HPV 58(11%) and HPV 16 (8.9%) in MSW. Prevalence of any HPV types in 9-valent vaccine types was higher among MSM than MSW (47.4% vs 22.1%. P = 0.001). Abnormal anal cytology was more commonly detected in MSM than MSW (42.9% vs.19.1%, P < 0.001). In HIV-infected MSM, higher number of lifetime male sex partners was significantly associated with any anal HPV infection, but age was a significant risk factor associated with anal HR-HPV infection. Conclusion: Anal HPV infection was highly prevalent in HIV-infected MSM in Korea, and also commonly found in HIV-infected MSW. In HIV-infected MSM, the significant risk factor for being infected with any HPV infection was lifetime number of male sexual partners, and with anal oncogenic HPV infection was age.

Original languageEnglish
Article numbere0161460
JournalPLoS ONE
Volume11
Issue number8
DOIs
StatePublished - Aug 2016

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    Lee, C. H., Lee, S. H., Lee, S., Cho, H., Kim, K. H., Lee, J. E., Jung, E. J., Lee, S. J., Kim, E. J., Kim, K. H., Moon, E., & Cho, H. J. (2016). Anal human papillomavirus infection among HIV-infected men in Korea. PLoS ONE, 11(8), [e0161460]. https://doi.org/10.1371/journal.pone.0161460