An outbreak of gnathostomiasis among Korean emigrants in Myanmar.

Jong Yil Chai, Eun Taek Han, Eunhee Shin, Jae Hwan Park, Jong Phil Chu, Masaki Hirota, Fukumi Nakamura-Uchiyama, Yukifumi Nawa

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

Abstract

Thirty-eight (designated as cases) of 60 Korean emigrants who consumed raw fresh water fish in Yangon, Myanmar developed migratory swellings and creeping eruptions on the back, abdomen, flank, and other cutaneous areas 1-10 weeks later. The symptoms included itching, nodule formation, fatigue, urticaria, fever, pain on the skin, and erythematous plaques. Skin biopsies of two cases revealed no parasites. However, the mean +/- SD peripheral blood eosinophilia among the cases was 6.3 +/- 6.5% (n = 29) and 9.0 +/- 9.8% (n = 26) in two examinations. An enzyme-linked immunosorbent assay of their serum samples, using Gnathostoma doloresi adult worms as the antigen, showed mean +/- SD optical densities of 0.47 +/- 0.29 (n = 28) and 0.32 +/- 0.20 (n = 30) in two examinations and 0.12 +/- 0.09 (n = 50) in healthy controls. Two advanced third-stage larvae of G. spinigerum were found in two of six catfish purchased at a local market in Yangon. The outbreak of the human infection is suggested to have been due to G. spinigerum, which is known to live out its life cycle in the Yangon area of Myanmar.

Original languageEnglish
Pages (from-to)67-73
Number of pages7
JournalThe American journal of tropical medicine and hygiene
Volume69
Issue number1
StatePublished - 1 Jan 2003

Fingerprint

Gnathostomiasis
Myanmar
Disease Outbreaks
Skin
Gnathostoma
Larva Migrans
Catfishes
Urticaria
Eosinophilia
Pruritus
Life Cycle Stages
Fresh Water
Abdomen
Fatigue
Larva
Fishes
Parasites
Fever
Enzyme-Linked Immunosorbent Assay
Biopsy

Cite this

Chai, J. Y., Han, E. T., Shin, E., Park, J. H., Chu, J. P., Hirota, M., ... Nawa, Y. (2003). An outbreak of gnathostomiasis among Korean emigrants in Myanmar. The American journal of tropical medicine and hygiene, 69(1), 67-73.
Chai, Jong Yil ; Han, Eun Taek ; Shin, Eunhee ; Park, Jae Hwan ; Chu, Jong Phil ; Hirota, Masaki ; Nakamura-Uchiyama, Fukumi ; Nawa, Yukifumi. / An outbreak of gnathostomiasis among Korean emigrants in Myanmar. In: The American journal of tropical medicine and hygiene. 2003 ; Vol. 69, No. 1. pp. 67-73.
@article{c56a9cfa246e4d8299cbeae759cc216a,
title = "An outbreak of gnathostomiasis among Korean emigrants in Myanmar.",
abstract = "Thirty-eight (designated as cases) of 60 Korean emigrants who consumed raw fresh water fish in Yangon, Myanmar developed migratory swellings and creeping eruptions on the back, abdomen, flank, and other cutaneous areas 1-10 weeks later. The symptoms included itching, nodule formation, fatigue, urticaria, fever, pain on the skin, and erythematous plaques. Skin biopsies of two cases revealed no parasites. However, the mean +/- SD peripheral blood eosinophilia among the cases was 6.3 +/- 6.5{\%} (n = 29) and 9.0 +/- 9.8{\%} (n = 26) in two examinations. An enzyme-linked immunosorbent assay of their serum samples, using Gnathostoma doloresi adult worms as the antigen, showed mean +/- SD optical densities of 0.47 +/- 0.29 (n = 28) and 0.32 +/- 0.20 (n = 30) in two examinations and 0.12 +/- 0.09 (n = 50) in healthy controls. Two advanced third-stage larvae of G. spinigerum were found in two of six catfish purchased at a local market in Yangon. The outbreak of the human infection is suggested to have been due to G. spinigerum, which is known to live out its life cycle in the Yangon area of Myanmar.",
author = "Chai, {Jong Yil} and Han, {Eun Taek} and Eunhee Shin and Park, {Jae Hwan} and Chu, {Jong Phil} and Masaki Hirota and Fukumi Nakamura-Uchiyama and Yukifumi Nawa",
year = "2003",
month = "1",
day = "1",
language = "English",
volume = "69",
pages = "67--73",
journal = "American Journal of Tropical Medicine and Hygiene",
issn = "0002-9637",
publisher = "American Society of Tropical Medicine and Hygiene",
number = "1",

}

Chai, JY, Han, ET, Shin, E, Park, JH, Chu, JP, Hirota, M, Nakamura-Uchiyama, F & Nawa, Y 2003, 'An outbreak of gnathostomiasis among Korean emigrants in Myanmar.', The American journal of tropical medicine and hygiene, vol. 69, no. 1, pp. 67-73.

An outbreak of gnathostomiasis among Korean emigrants in Myanmar. / Chai, Jong Yil; Han, Eun Taek; Shin, Eunhee; Park, Jae Hwan; Chu, Jong Phil; Hirota, Masaki; Nakamura-Uchiyama, Fukumi; Nawa, Yukifumi.

In: The American journal of tropical medicine and hygiene, Vol. 69, No. 1, 01.01.2003, p. 67-73.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - An outbreak of gnathostomiasis among Korean emigrants in Myanmar.

AU - Chai, Jong Yil

AU - Han, Eun Taek

AU - Shin, Eunhee

AU - Park, Jae Hwan

AU - Chu, Jong Phil

AU - Hirota, Masaki

AU - Nakamura-Uchiyama, Fukumi

AU - Nawa, Yukifumi

PY - 2003/1/1

Y1 - 2003/1/1

N2 - Thirty-eight (designated as cases) of 60 Korean emigrants who consumed raw fresh water fish in Yangon, Myanmar developed migratory swellings and creeping eruptions on the back, abdomen, flank, and other cutaneous areas 1-10 weeks later. The symptoms included itching, nodule formation, fatigue, urticaria, fever, pain on the skin, and erythematous plaques. Skin biopsies of two cases revealed no parasites. However, the mean +/- SD peripheral blood eosinophilia among the cases was 6.3 +/- 6.5% (n = 29) and 9.0 +/- 9.8% (n = 26) in two examinations. An enzyme-linked immunosorbent assay of their serum samples, using Gnathostoma doloresi adult worms as the antigen, showed mean +/- SD optical densities of 0.47 +/- 0.29 (n = 28) and 0.32 +/- 0.20 (n = 30) in two examinations and 0.12 +/- 0.09 (n = 50) in healthy controls. Two advanced third-stage larvae of G. spinigerum were found in two of six catfish purchased at a local market in Yangon. The outbreak of the human infection is suggested to have been due to G. spinigerum, which is known to live out its life cycle in the Yangon area of Myanmar.

AB - Thirty-eight (designated as cases) of 60 Korean emigrants who consumed raw fresh water fish in Yangon, Myanmar developed migratory swellings and creeping eruptions on the back, abdomen, flank, and other cutaneous areas 1-10 weeks later. The symptoms included itching, nodule formation, fatigue, urticaria, fever, pain on the skin, and erythematous plaques. Skin biopsies of two cases revealed no parasites. However, the mean +/- SD peripheral blood eosinophilia among the cases was 6.3 +/- 6.5% (n = 29) and 9.0 +/- 9.8% (n = 26) in two examinations. An enzyme-linked immunosorbent assay of their serum samples, using Gnathostoma doloresi adult worms as the antigen, showed mean +/- SD optical densities of 0.47 +/- 0.29 (n = 28) and 0.32 +/- 0.20 (n = 30) in two examinations and 0.12 +/- 0.09 (n = 50) in healthy controls. Two advanced third-stage larvae of G. spinigerum were found in two of six catfish purchased at a local market in Yangon. The outbreak of the human infection is suggested to have been due to G. spinigerum, which is known to live out its life cycle in the Yangon area of Myanmar.

UR - http://www.scopus.com/inward/record.url?scp=0042866141&partnerID=8YFLogxK

M3 - Article

VL - 69

SP - 67

EP - 73

JO - American Journal of Tropical Medicine and Hygiene

JF - American Journal of Tropical Medicine and Hygiene

SN - 0002-9637

IS - 1

ER -