Altered synaptic connections and inhibitory network of the primary somatosensory cortex in chronic pain

Yoo Rim Kim, Sang Jeong Kim

Research output: Contribution to journalReview articlepeer-review

Abstract

Chronic pain is induced by tissue or nerve damage and is accompanied by pain hypersensitivity (i.e., allodynia and hyperalgesia). Previous studies using in vivo two-photon microscopy have shown functional and structural changes in the primary somatosensory (S1) cortex at the cellular and synaptic levels in inflammatory and neuropathic chronic pain. Furthermore, alterations in local cortical circuits were revealed during the development of chronic pain. In this review, we summarize recent findings regarding functional and structural plastic changes of the S1 cortex and alteration of the S1 inhibitory network in chronic pain. Finally, we discuss potential neuromodulators driving modified cortical circuits and suggest further studies to understand the cortical mechanisms that induce pain hypersensitivity.

Original languageEnglish
Pages (from-to)69-75
Number of pages7
JournalKorean Journal of Physiology and Pharmacology
Volume26
Issue number2
DOIs
StatePublished - Mar 2022

Keywords

  • Chronic pain
  • Cortical circuit
  • Inhibitory network
  • Neuropathic pain
  • Primary somatosensory cortex

Fingerprint

Dive into the research topics of 'Altered synaptic connections and inhibitory network of the primary somatosensory cortex in chronic pain'. Together they form a unique fingerprint.

Cite this