Altered resting-state thalamo-occipital functional connectivity is associated with cognition in isolated rapid eye movement sleep behavior disorder

Jung Ick Byun, Hyun Woo Kim, Hyejin Kang, Kwang Su Cha, Jun Sang Sunwoo, Jung Won Shin, Jangsup Moon, Soon Tae Lee, Keun Hwa Jung, Kon Chu, Manho Kim, Won Chul Shin, Dong Soo Lee, Carlos H. Schenck, Sang Kun Lee, Ki Young Jung

Research output: Contribution to journalArticle

Abstract

Objective: Isolated rapid eye movement sleep behavior disorder (iRBD) patients are at risk of cognitive impairments, however the underlying mechanism is still unclear. This study aimed to evaluate thalamo-cortical functional connectivity (FC) using resting-state functional magnetic resonance imaging (fMRI) and its correlation with cognitive dysfunction in patients with iRBD. Methods: A total 37 polysomnographies (PSGs) confirmed iRBD patients and 15 age-sex matched controls underwent resting-state fMRI and comprehensive neuropsychological assessment. Thalamo-cortical FC was evaluated by using seed-to voxel analysis and was compared between the iRBD and controls. Correlation between the average value of significant clusters and cognitive function scores in iRBD were calculated. Results: Compared to the control subjects, patients with iRBD patients showed cognitive decline in word list recognition (p = 0.016), and constructional recall (p = 0.044). The FC analysis showed increased FC between the left thalamus and occipital regions including the right cuneal cortex, left fusiform gyrus and lingual gyrus (cluster level p < 0.05, corrected for false discovery rate). The averaged thalamo-fusiform FC value positively correlated with word list recognition after adjusting for age and sex (adjusted r = 0.347, p = 0.041). Conclusion: Thalamic resting state FC is altered in iRBD patients and is associated with the cognitive function. Enhancement of the thalamo-occipital FC may reflect a compensatory mechanism for cognitive impairment in iRBD.

Original languageEnglish
Pages (from-to)198-203
Number of pages6
JournalSleep Medicine
Volume69
DOIs
StatePublished - May 2020

    Fingerprint

Keywords

  • Cognitive function
  • Functional brain imaging
  • Neuroimaging
  • REM sleep behavior disorder

Cite this

Byun, J. I., Kim, H. W., Kang, H., Cha, K. S., Sunwoo, J. S., Shin, J. W., Moon, J., Lee, S. T., Jung, K. H., Chu, K., Kim, M., Shin, W. C., Lee, D. S., Schenck, C. H., Lee, S. K., & Jung, K. Y. (2020). Altered resting-state thalamo-occipital functional connectivity is associated with cognition in isolated rapid eye movement sleep behavior disorder. Sleep Medicine, 69, 198-203. https://doi.org/10.1016/j.sleep.2020.01.010