Alcohol Consumption and Progression of Chronic Kidney Disease: Results From the Korean Cohort Study for Outcome in Patients with Chronic Kidney Disease

Young Su Joo, Heebyung Koh, Ki Heon Nam, Sangmi Lee, Joohwan Kim, Changhyun Lee, Hae Ryong Yun, Jung Tak Park, Ea Wha Kang, Tae Ik Chang, Tae Hyun Yoo, Kook Hwan Oh, Dong Wan Chae, Kyu Beck Lee, Soo Wan Kim, Joongyub Lee, Shin Wook Kang, Kyu Hun Choi, Curie Ahn, Seung Hyeok Han

Research output: Contribution to journalArticle

Abstract

Objective: To assess the association of alcohol consumption with chronic kidney disease (CKD) progression in patients with CKD. Patients and Methods: The KoreaN cohort study for Outcome in patients with CKD (KNOW-CKD) is a prospective observational study that included detailed questionnaires regarding alcohol consumption. The 1883 individuals with CKD were enrolled from April 1, 2011, through February 28, 2016, and followed until May 31, 2017. Using a questionnaire, alcohol consumption pattern was classified according to the amount of alcohol per occasion (none, moderate, or binge) or drinking frequency (none, occasional, or regular). The primary endpoint was a composite of 50% or greater decline in estimated glomerular filtration rate (eGFR) from the baseline level or end-stage renal disease. Results: During a follow-up of 5555 person-years (median, 2.95 years), the primary outcome occurred in 419 patients. Unadjusted cause-specific hazards model showed that the risk of the primary outcome was lower in drinkers than in non-drinkers. However, a fully adjusted model including eGFR and proteinuria yielded a reverse association. Compared with non-drinking, regular and occasional binge drinking were associated with a 2.2-fold (95% CI, 1.38-3.46) and a 2.0-fold (95% CI, 1.33-2.98) higher risk of CKD progression, respectively. This association was particularly evident in patients who had decreased kidney function and proteinuria. There was a significant interaction between alcohol consumption and eGFR for CKD progression. The slopes of eGFR decline were steeper in binge drinkers among patients with eGFR less than 60 mL/min/1.73 m2. Conclusions: Heavy alcohol consumption was associated with faster progression of CKD.

Original languageEnglish
Pages (from-to)293-305
Number of pages13
JournalMayo Clinic Proceedings
Volume95
Issue number2
DOIs
StatePublished - Feb 2020

Fingerprint

Chronic Renal Insufficiency
Alcohol Drinking
Cohort Studies
Glomerular Filtration Rate
Binge Drinking
Disease Progression
Proteinuria
Proportional Hazards Models
Chronic Kidney Failure
Observational Studies
Alcohols
Prospective Studies
Kidney

Cite this

Joo, Young Su ; Koh, Heebyung ; Nam, Ki Heon ; Lee, Sangmi ; Kim, Joohwan ; Lee, Changhyun ; Yun, Hae Ryong ; Park, Jung Tak ; Kang, Ea Wha ; Chang, Tae Ik ; Yoo, Tae Hyun ; Oh, Kook Hwan ; Chae, Dong Wan ; Lee, Kyu Beck ; Kim, Soo Wan ; Lee, Joongyub ; Kang, Shin Wook ; Choi, Kyu Hun ; Ahn, Curie ; Han, Seung Hyeok. / Alcohol Consumption and Progression of Chronic Kidney Disease : Results From the Korean Cohort Study for Outcome in Patients with Chronic Kidney Disease. In: Mayo Clinic Proceedings. 2020 ; Vol. 95, No. 2. pp. 293-305.
@article{b00473df2639470c8770168e8c46ee11,
title = "Alcohol Consumption and Progression of Chronic Kidney Disease: Results From the Korean Cohort Study for Outcome in Patients with Chronic Kidney Disease",
abstract = "Objective: To assess the association of alcohol consumption with chronic kidney disease (CKD) progression in patients with CKD. Patients and Methods: The KoreaN cohort study for Outcome in patients with CKD (KNOW-CKD) is a prospective observational study that included detailed questionnaires regarding alcohol consumption. The 1883 individuals with CKD were enrolled from April 1, 2011, through February 28, 2016, and followed until May 31, 2017. Using a questionnaire, alcohol consumption pattern was classified according to the amount of alcohol per occasion (none, moderate, or binge) or drinking frequency (none, occasional, or regular). The primary endpoint was a composite of 50{\%} or greater decline in estimated glomerular filtration rate (eGFR) from the baseline level or end-stage renal disease. Results: During a follow-up of 5555 person-years (median, 2.95 years), the primary outcome occurred in 419 patients. Unadjusted cause-specific hazards model showed that the risk of the primary outcome was lower in drinkers than in non-drinkers. However, a fully adjusted model including eGFR and proteinuria yielded a reverse association. Compared with non-drinking, regular and occasional binge drinking were associated with a 2.2-fold (95{\%} CI, 1.38-3.46) and a 2.0-fold (95{\%} CI, 1.33-2.98) higher risk of CKD progression, respectively. This association was particularly evident in patients who had decreased kidney function and proteinuria. There was a significant interaction between alcohol consumption and eGFR for CKD progression. The slopes of eGFR decline were steeper in binge drinkers among patients with eGFR less than 60 mL/min/1.73 m2. Conclusions: Heavy alcohol consumption was associated with faster progression of CKD.",
author = "Joo, {Young Su} and Heebyung Koh and Nam, {Ki Heon} and Sangmi Lee and Joohwan Kim and Changhyun Lee and Yun, {Hae Ryong} and Park, {Jung Tak} and Kang, {Ea Wha} and Chang, {Tae Ik} and Yoo, {Tae Hyun} and Oh, {Kook Hwan} and Chae, {Dong Wan} and Lee, {Kyu Beck} and Kim, {Soo Wan} and Joongyub Lee and Kang, {Shin Wook} and Choi, {Kyu Hun} and Curie Ahn and Han, {Seung Hyeok}",
year = "2020",
month = "2",
doi = "10.1016/j.mayocp.2019.06.014",
language = "English",
volume = "95",
pages = "293--305",
journal = "Mayo Clinic Proceedings",
issn = "0025-6196",
publisher = "Elsevier Science",
number = "2",

}

Joo, YS, Koh, H, Nam, KH, Lee, S, Kim, J, Lee, C, Yun, HR, Park, JT, Kang, EW, Chang, TI, Yoo, TH, Oh, KH, Chae, DW, Lee, KB, Kim, SW, Lee, J, Kang, SW, Choi, KH, Ahn, C & Han, SH 2020, 'Alcohol Consumption and Progression of Chronic Kidney Disease: Results From the Korean Cohort Study for Outcome in Patients with Chronic Kidney Disease', Mayo Clinic Proceedings, vol. 95, no. 2, pp. 293-305. https://doi.org/10.1016/j.mayocp.2019.06.014

Alcohol Consumption and Progression of Chronic Kidney Disease : Results From the Korean Cohort Study for Outcome in Patients with Chronic Kidney Disease. / Joo, Young Su; Koh, Heebyung; Nam, Ki Heon; Lee, Sangmi; Kim, Joohwan; Lee, Changhyun; Yun, Hae Ryong; Park, Jung Tak; Kang, Ea Wha; Chang, Tae Ik; Yoo, Tae Hyun; Oh, Kook Hwan; Chae, Dong Wan; Lee, Kyu Beck; Kim, Soo Wan; Lee, Joongyub; Kang, Shin Wook; Choi, Kyu Hun; Ahn, Curie; Han, Seung Hyeok.

In: Mayo Clinic Proceedings, Vol. 95, No. 2, 02.2020, p. 293-305.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Alcohol Consumption and Progression of Chronic Kidney Disease

T2 - Results From the Korean Cohort Study for Outcome in Patients with Chronic Kidney Disease

AU - Joo, Young Su

AU - Koh, Heebyung

AU - Nam, Ki Heon

AU - Lee, Sangmi

AU - Kim, Joohwan

AU - Lee, Changhyun

AU - Yun, Hae Ryong

AU - Park, Jung Tak

AU - Kang, Ea Wha

AU - Chang, Tae Ik

AU - Yoo, Tae Hyun

AU - Oh, Kook Hwan

AU - Chae, Dong Wan

AU - Lee, Kyu Beck

AU - Kim, Soo Wan

AU - Lee, Joongyub

AU - Kang, Shin Wook

AU - Choi, Kyu Hun

AU - Ahn, Curie

AU - Han, Seung Hyeok

PY - 2020/2

Y1 - 2020/2

N2 - Objective: To assess the association of alcohol consumption with chronic kidney disease (CKD) progression in patients with CKD. Patients and Methods: The KoreaN cohort study for Outcome in patients with CKD (KNOW-CKD) is a prospective observational study that included detailed questionnaires regarding alcohol consumption. The 1883 individuals with CKD were enrolled from April 1, 2011, through February 28, 2016, and followed until May 31, 2017. Using a questionnaire, alcohol consumption pattern was classified according to the amount of alcohol per occasion (none, moderate, or binge) or drinking frequency (none, occasional, or regular). The primary endpoint was a composite of 50% or greater decline in estimated glomerular filtration rate (eGFR) from the baseline level or end-stage renal disease. Results: During a follow-up of 5555 person-years (median, 2.95 years), the primary outcome occurred in 419 patients. Unadjusted cause-specific hazards model showed that the risk of the primary outcome was lower in drinkers than in non-drinkers. However, a fully adjusted model including eGFR and proteinuria yielded a reverse association. Compared with non-drinking, regular and occasional binge drinking were associated with a 2.2-fold (95% CI, 1.38-3.46) and a 2.0-fold (95% CI, 1.33-2.98) higher risk of CKD progression, respectively. This association was particularly evident in patients who had decreased kidney function and proteinuria. There was a significant interaction between alcohol consumption and eGFR for CKD progression. The slopes of eGFR decline were steeper in binge drinkers among patients with eGFR less than 60 mL/min/1.73 m2. Conclusions: Heavy alcohol consumption was associated with faster progression of CKD.

AB - Objective: To assess the association of alcohol consumption with chronic kidney disease (CKD) progression in patients with CKD. Patients and Methods: The KoreaN cohort study for Outcome in patients with CKD (KNOW-CKD) is a prospective observational study that included detailed questionnaires regarding alcohol consumption. The 1883 individuals with CKD were enrolled from April 1, 2011, through February 28, 2016, and followed until May 31, 2017. Using a questionnaire, alcohol consumption pattern was classified according to the amount of alcohol per occasion (none, moderate, or binge) or drinking frequency (none, occasional, or regular). The primary endpoint was a composite of 50% or greater decline in estimated glomerular filtration rate (eGFR) from the baseline level or end-stage renal disease. Results: During a follow-up of 5555 person-years (median, 2.95 years), the primary outcome occurred in 419 patients. Unadjusted cause-specific hazards model showed that the risk of the primary outcome was lower in drinkers than in non-drinkers. However, a fully adjusted model including eGFR and proteinuria yielded a reverse association. Compared with non-drinking, regular and occasional binge drinking were associated with a 2.2-fold (95% CI, 1.38-3.46) and a 2.0-fold (95% CI, 1.33-2.98) higher risk of CKD progression, respectively. This association was particularly evident in patients who had decreased kidney function and proteinuria. There was a significant interaction between alcohol consumption and eGFR for CKD progression. The slopes of eGFR decline were steeper in binge drinkers among patients with eGFR less than 60 mL/min/1.73 m2. Conclusions: Heavy alcohol consumption was associated with faster progression of CKD.

UR - http://www.scopus.com/inward/record.url?scp=85077171431&partnerID=8YFLogxK

U2 - 10.1016/j.mayocp.2019.06.014

DO - 10.1016/j.mayocp.2019.06.014

M3 - Article

AN - SCOPUS:85077171431

VL - 95

SP - 293

EP - 305

JO - Mayo Clinic Proceedings

JF - Mayo Clinic Proceedings

SN - 0025-6196

IS - 2

ER -