Age-related changes in glycogen synthase kinase 3β (GSK3β) immunoreactivity in the central nervous system of rats

Soo Joo Lee, Yoon Hee Chung, Kyeung Min Joo, Heon Chang Lim, Gye Sun Jeon, Daejin Kim, Won Bok Lee, Yong Sik Kim, Choong Ik Cha

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Although glycogen synthase kinase 3β (GSK3β) is emerging as a prominent drug target in the treatment of neurodegenerative diseases such as Alzheimer's disease (AD) and stroke, very little is known about age-related changes in GSK3β expression and GSK3β phosphorylation. Therefore, we examined age-related changes in immunoreactivities for GSK3β and phosphorylated GSK3β (pGSK3β) in the central nervous system. In aged rats, there were significant increases in GSK3β immunoreactivity in the cell bodies and processes of pyramidal cells in most cortical regions. GSK3β immunoreactivity was also significantly increased in the pyramidal layer of CA1-3 regions, and the granule cell layer of dentate gyrus. Age-related increases were prominent in lateral septal nuclei, compared to the medial septal nuclei. Interestingly, both GSK3β and pGSK3β was increased in the prefrontal cortex, while GSK3β and pGSK3β was differentially localized in the cerebellar cortex. The first demonstration of age-related alterations in immunoreactivities for GSK3β and pGSK3β in the basal forebrain area and cholinergic projection targets may provide useful data for investigating the pathogenesis of age-related neurodegenerative diseases including AD.

Original languageEnglish
Pages (from-to)134-139
Number of pages6
JournalNeuroscience Letters
Volume409
Issue number2
DOIs
StatePublished - 1 Dec 2006

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Glycogen Synthase Kinase 3
Central Nervous System
Septal Nuclei
Neurodegenerative Diseases
Alzheimer Disease
Cerebellar Cortex
Pyramidal Cells
Dentate Gyrus
Prefrontal Cortex
Cholinergic Agents
Stroke
Phosphorylation

Keywords

  • Aging
  • Cerebral cortex
  • Glycogen synthase kinase 3β (GSK3β)
  • Hippocampus
  • Rat
  • Septal nuclei

Cite this

Lee, Soo Joo ; Chung, Yoon Hee ; Joo, Kyeung Min ; Lim, Heon Chang ; Jeon, Gye Sun ; Kim, Daejin ; Lee, Won Bok ; Kim, Yong Sik ; Cha, Choong Ik. / Age-related changes in glycogen synthase kinase 3β (GSK3β) immunoreactivity in the central nervous system of rats. In: Neuroscience Letters. 2006 ; Vol. 409, No. 2. pp. 134-139.
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Age-related changes in glycogen synthase kinase 3β (GSK3β) immunoreactivity in the central nervous system of rats. / Lee, Soo Joo; Chung, Yoon Hee; Joo, Kyeung Min; Lim, Heon Chang; Jeon, Gye Sun; Kim, Daejin; Lee, Won Bok; Kim, Yong Sik; Cha, Choong Ik.

In: Neuroscience Letters, Vol. 409, No. 2, 01.12.2006, p. 134-139.

Research output: Contribution to journalArticle

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AU - Jeon, Gye Sun

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AU - Kim, Yong Sik

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