Age-Dependent Variation of Lamina Cribrosa Displacement During the Standardized Valsalva Maneuver

Yong Woo Kim, Dong Hyun Lee, Hyung Bin Lim, Baek Lok Oh, Young Kook Kim, Michael J.A. Girard, Jean Martial Mari, Ki Ho Park, Jin Wook Jeoung

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Based on biomechanical theory, lamina cribrosa (LC) displacement, the key component of progressive glaucomatous change, is presumed to be dependent on intraocular pressure (IOP) as well as tissue stiffness of LC. In the performance of the Valsalva maneuver, both IOP and cerebrospinal fluid pressure can increase. The present study investigated the age-dependent variation of LC displacement during the standardized Valsalva maneuver in healthy subjects. Sixty-three (63) eyes (age range: 20–76 years) were prospectively underwent IOP measurement and Cirrus HD-OCT optic disc scans before and during the standardized Valsalva maneuver. During the standardized Valsalva maneuver, the IOP significantly increased from 13.2 ± 2.9 mmHg to 18.6 ± 5.2 mmHg (P < 0.001). The maximal LC depth significantly decreased in the younger age groups (age: 20 s to 40 s) but not in the older age groups (age: over 50). The BMO distance did not change significantly. Younger age (P = 0.009), a smaller increase of IOP during the Valsalva maneuver (P = 0.002), and greater baseline maximal LC depth (P = 0.013) were associated with more anterior displacement of the LC during the standardized Valsalva maneuver. Taken together, age as well as translaminar pressure dynamics seems to play a crucial role in LC biomechanics.

Original languageEnglish
Article number6645
Pages (from-to)6645
JournalScientific Reports
Volume9
Issue number1
DOIs
StatePublished - 30 Apr 2019

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Valsalva Maneuver
Intraocular Pressure
Age Groups
Cerebrospinal Fluid Pressure
Aqueous Humor
Optic Disk
Biomechanical Phenomena
Healthy Volunteers
Pressure

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Kim, Yong Woo ; Lee, Dong Hyun ; Lim, Hyung Bin ; Oh, Baek Lok ; Kim, Young Kook ; Girard, Michael J.A. ; Mari, Jean Martial ; Park, Ki Ho ; Jeoung, Jin Wook. / Age-Dependent Variation of Lamina Cribrosa Displacement During the Standardized Valsalva Maneuver. In: Scientific Reports. 2019 ; Vol. 9, No. 1. pp. 6645.
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abstract = "Based on biomechanical theory, lamina cribrosa (LC) displacement, the key component of progressive glaucomatous change, is presumed to be dependent on intraocular pressure (IOP) as well as tissue stiffness of LC. In the performance of the Valsalva maneuver, both IOP and cerebrospinal fluid pressure can increase. The present study investigated the age-dependent variation of LC displacement during the standardized Valsalva maneuver in healthy subjects. Sixty-three (63) eyes (age range: 20–76 years) were prospectively underwent IOP measurement and Cirrus HD-OCT optic disc scans before and during the standardized Valsalva maneuver. During the standardized Valsalva maneuver, the IOP significantly increased from 13.2 ± 2.9 mmHg to 18.6 ± 5.2 mmHg (P < 0.001). The maximal LC depth significantly decreased in the younger age groups (age: 20 s to 40 s) but not in the older age groups (age: over 50). The BMO distance did not change significantly. Younger age (P = 0.009), a smaller increase of IOP during the Valsalva maneuver (P = 0.002), and greater baseline maximal LC depth (P = 0.013) were associated with more anterior displacement of the LC during the standardized Valsalva maneuver. Taken together, age as well as translaminar pressure dynamics seems to play a crucial role in LC biomechanics.",
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Age-Dependent Variation of Lamina Cribrosa Displacement During the Standardized Valsalva Maneuver. / Kim, Yong Woo; Lee, Dong Hyun; Lim, Hyung Bin; Oh, Baek Lok; Kim, Young Kook; Girard, Michael J.A.; Mari, Jean Martial; Park, Ki Ho; Jeoung, Jin Wook.

In: Scientific Reports, Vol. 9, No. 1, 6645, 30.04.2019, p. 6645.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Kim, Yong Woo

AU - Lee, Dong Hyun

AU - Lim, Hyung Bin

AU - Oh, Baek Lok

AU - Kim, Young Kook

AU - Girard, Michael J.A.

AU - Mari, Jean Martial

AU - Park, Ki Ho

AU - Jeoung, Jin Wook

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