Adjuvant chemotherapy in the management of pT3N0M0 transitional cell carcinoma of the upper urinary tract

Eun Lee Sang, Seok-Soo Byun, Hyun Park Yong, Ho Chang In, June Kim Yong, Sung Kyu Hong

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Introduction: We investigate the efficacy of postoperative adjuvant chemotherapy for locally advanced, but lymph node negative, pathologic stage T3 transitional cell carcinoma (TCC) of the upper urinary tract. Patients and Methods: A retrospective study on 27 patients who had undergone radical nephroureterectomy with regional lymphadenectomy for pT3N0M0 primary upper urinary tract TCC at our institution from 1996 to 2001 was performed. Among the 27 patients, 16 also received adjuvant chemotherapy following surgery (adjuvant group), whereas the other 11 patients did not (nonadjuvant group). Results: Adjuvant and nonadjuvant therapy groups were not significantly different with respect to age, sex, performance status, tumor grade, and tumor location. Overall, 5 of the 16 patients (31%) in the adjuvant group and 4 of the 11 patients (36%) in the nonadjuvant group had recurrence of cancer at 40 months of follow-up. The two groups demonstrated no significant differences in recurrence-free survival (p = 0.794) and disease-specific survival (p = 0.783). Conclusions: Although it would be difficult to draw any definite conclusions from the results of our investigations, our data suggest that adjuvant therapy with traditional conventional chemotherapeutic regimens alone may not be effective as previously anticipated in significantly improving survival rates for locally advanced, but lymph node negative, TCC of the upper urinary tract.

Original languageEnglish
Pages (from-to)22-26
Number of pages5
JournalUrologia Internationalis
Volume77
Issue number1
DOIs
StatePublished - 1 Jul 2006

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Transitional Cell Carcinoma
Adjuvant Chemotherapy
Urinary Tract
Lymph Nodes
Recurrence
Neoplasms
Survival
Group Psychotherapy
Lymph Node Excision
Survival Rate
Retrospective Studies

Keywords

  • Adjuvant chemotherapy, upper urinary tract transitional cell carcinoma
  • Radical nephroureterectomy/regional lymphadenectomy
  • Transitional cell carcinoma, upper urinary tract

Cite this

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abstract = "Introduction: We investigate the efficacy of postoperative adjuvant chemotherapy for locally advanced, but lymph node negative, pathologic stage T3 transitional cell carcinoma (TCC) of the upper urinary tract. Patients and Methods: A retrospective study on 27 patients who had undergone radical nephroureterectomy with regional lymphadenectomy for pT3N0M0 primary upper urinary tract TCC at our institution from 1996 to 2001 was performed. Among the 27 patients, 16 also received adjuvant chemotherapy following surgery (adjuvant group), whereas the other 11 patients did not (nonadjuvant group). Results: Adjuvant and nonadjuvant therapy groups were not significantly different with respect to age, sex, performance status, tumor grade, and tumor location. Overall, 5 of the 16 patients (31{\%}) in the adjuvant group and 4 of the 11 patients (36{\%}) in the nonadjuvant group had recurrence of cancer at 40 months of follow-up. The two groups demonstrated no significant differences in recurrence-free survival (p = 0.794) and disease-specific survival (p = 0.783). Conclusions: Although it would be difficult to draw any definite conclusions from the results of our investigations, our data suggest that adjuvant therapy with traditional conventional chemotherapeutic regimens alone may not be effective as previously anticipated in significantly improving survival rates for locally advanced, but lymph node negative, TCC of the upper urinary tract.",
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Adjuvant chemotherapy in the management of pT3N0M0 transitional cell carcinoma of the upper urinary tract. / Sang, Eun Lee; Byun, Seok-Soo; Yong, Hyun Park; In, Ho Chang; Yong, June Kim; Hong, Sung Kyu.

In: Urologia Internationalis, Vol. 77, No. 1, 01.07.2006, p. 22-26.

Research output: Contribution to journalArticle

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T1 - Adjuvant chemotherapy in the management of pT3N0M0 transitional cell carcinoma of the upper urinary tract

AU - Sang, Eun Lee

AU - Byun, Seok-Soo

AU - Yong, Hyun Park

AU - In, Ho Chang

AU - Yong, June Kim

AU - Hong, Sung Kyu

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