Adjuvant chemotherapy does not provide survival benefits to elderly patients with stage II colon cancer

Kil yong Lee, Ji Won Park, Ki young Lee, Sangsik Cho, Yoon Hye Kwon, Min Jung Kim, Seung Bum Ryoo, Seung-Yong Jeong, Kyu Joo Park

Research output: Contribution to journalArticle

Abstract

To date, the effect of adjuvant chemotherapy after curative resection in patients with stage II colon cancer remains controversial. Still, little is known about the effects of adjuvant chemotherapy in patients with stage II colon cancer who are older than 70 years, as most studies did not focus on this population. This study aimed to investigate the oncologic outcomes of elderly patients with stage II colon cancer who underwent curative resection with or without postoperative adjuvant chemotherapy. We retrospectively reviewed medical records of patients older than 70 years who underwent curative resection of stage II primary colon cancer during 2002–2015. Patients were classified into surgery alone (SA) and adjuvant chemotherapy (AC) groups and propensity score-matched at a 1:1 ratio using a logistic regression. The end points were recurrence-free (RFS), cancer-specific (CSS) and overall survival (OS). Of the 623 patients who met the criteria, 145 were assigned to each arm after propensity score matching. The mean ages of the SA and AC groups were 74.3 and 74.0 years, respectively. A log-rank test revealed no significant inter-group differences in RFS (p = 0.202), CSS (p = 0.486) or OS (p = 0.299). In a Cox regression analysis, adjuvant chemotherapy was not found to be an independent factor affecting RFS (p = 0.206), CSS (p = 0.487) or OS (p = 0.301). Adjuvant chemotherapy does not appear to yield survival benefits in elderly patients with stage II colon cancer.

Original languageEnglish
Article number11846
JournalScientific Reports
Volume9
Issue number1
DOIs
StatePublished - 1 Dec 2019

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Adjuvant Chemotherapy
Colonic Neoplasms
Survival
Propensity Score
Medical Records
Logistic Models
Regression Analysis
Recurrence
Population
Neoplasms

Cite this

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title = "Adjuvant chemotherapy does not provide survival benefits to elderly patients with stage II colon cancer",
abstract = "To date, the effect of adjuvant chemotherapy after curative resection in patients with stage II colon cancer remains controversial. Still, little is known about the effects of adjuvant chemotherapy in patients with stage II colon cancer who are older than 70 years, as most studies did not focus on this population. This study aimed to investigate the oncologic outcomes of elderly patients with stage II colon cancer who underwent curative resection with or without postoperative adjuvant chemotherapy. We retrospectively reviewed medical records of patients older than 70 years who underwent curative resection of stage II primary colon cancer during 2002–2015. Patients were classified into surgery alone (SA) and adjuvant chemotherapy (AC) groups and propensity score-matched at a 1:1 ratio using a logistic regression. The end points were recurrence-free (RFS), cancer-specific (CSS) and overall survival (OS). Of the 623 patients who met the criteria, 145 were assigned to each arm after propensity score matching. The mean ages of the SA and AC groups were 74.3 and 74.0 years, respectively. A log-rank test revealed no significant inter-group differences in RFS (p = 0.202), CSS (p = 0.486) or OS (p = 0.299). In a Cox regression analysis, adjuvant chemotherapy was not found to be an independent factor affecting RFS (p = 0.206), CSS (p = 0.487) or OS (p = 0.301). Adjuvant chemotherapy does not appear to yield survival benefits in elderly patients with stage II colon cancer.",
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Adjuvant chemotherapy does not provide survival benefits to elderly patients with stage II colon cancer. / Lee, Kil yong; Park, Ji Won; Lee, Ki young; Cho, Sangsik; Kwon, Yoon Hye; Kim, Min Jung; Ryoo, Seung Bum; Jeong, Seung-Yong; Park, Kyu Joo.

In: Scientific Reports, Vol. 9, No. 1, 11846, 01.12.2019.

Research output: Contribution to journalArticle

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AU - Lee, Kil yong

AU - Park, Ji Won

AU - Lee, Ki young

AU - Cho, Sangsik

AU - Kwon, Yoon Hye

AU - Kim, Min Jung

AU - Ryoo, Seung Bum

AU - Jeong, Seung-Yong

AU - Park, Kyu Joo

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