Adherence to and Dropout from Liraglutide 3.0 mg Obesity Treatment in a Real-World Setting

Hae Jin Ko, Jin Wook Kim, Soo Lim

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The factors associated with non-adherence to obesity treatment using liraglutide 3.0 mg in a real-world setting remain elusive. Methods: We performed a secondary data analysis of 769 participants treated with liraglutide 3.0 mg from December 2017 to June 2020 at nine Korean hospitals. Data were collected 2, 4, and 6 months after treatment initiation. Adherence groups were defined as <2, 2-4, 4-6, and ≥6 months. Results: Among the 769 patients, 539 (70.1%) were lost to follow-up within 6 months because of unknown reasons (54.2%), adverse events (14.8%), change of treatment (13.7%), or discontinuation due to poor weight loss (9.3%). Dropout at 6 months was significantly associated with the presence of diabetes mellitus in step 1 and the presence of diabetes mellitus with regular exercise in step 2 of the logistic regression analysis using the forward stepwise selection method. After adjusting for covariates, the presence of diabetes mellitus (odds ratio [OR], 0.25; 95% confidence interval [CI], 0.10-0.63; OR, 0.47; 95% CI, 0.31-0.73; and OR, 0.52; 95% CI, 0.34-0.80) and regular exercise (OR, 2.86; 95% CI, 1.31-6.23; OR, 2.09; 95% CI, 1.26-3.48; and OR, 2.99; 95% CI, 1.81-4.92) showed significant associations in the <2, 2-4, and 4-6 groups compared with the highest adherence group (≥6 months). Conclusion: Non-adherence to obesity treatment with liraglutide is related to regular exercise and absence of diabetes mellitus. Further prospective studies are warranted to increase medication adherence in those groups.

Original languageEnglish
Pages (from-to)254-262
Number of pages9
JournalJournal of Obesity and Metabolic Syndrome
Volume31
Issue number3
DOIs
StatePublished - Sep 2022
Externally publishedYes

Keywords

  • Diabetes mellitus
  • Exercise
  • Liraglutide
  • Lost to follow-up
  • Medication adherence

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