Additive diagnostic role of imaging in glaucoma: Optical coherence tomography and retinal nerve fiber layer photography

Ko Eun Kim, Seok Hwan Kim, Sohee Oh, Jin Wook Jeoung, Min Hee Suh, Je Hyun Seo, Martha Kim, Ki Ho Park, Dong Myung Kim

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Purpose: To investigate the additive diagnostic role of spectral-domain optical coherence tomography (SD-OCT) and red-free retinal nerve fiber layer photography (RNFLP) in making clinical glaucoma diagnosis.

Methods: Four diagnostic combination sets, including the most recent image from each measurement of 196 glaucoma eyes (including the 44 preperimetric glaucoma eyes) and 101 healthy eyes, were prepared: (1) stereo disc photography and Humphrey visual field (SH), (2) SH and SD-OCT (SHO), (3) SH and RNFLP (SHR), and (4) SHR and SD-OCT (SHRO). Each randomly sorted set was serially presented at 1-month intervals to five glaucoma specialists who were asked to evaluate them in a subjective and independent manner. The specialists' glaucoma-diagnostic performances based on the sets were then compared.

Results: For each specialist, adding SD-OCT to SH or SHR increased the glaucoma-diagnostic sensitivity but not to a level of statistical significance. For one specialist, adding RNFLP to SH significantly increased the sensitivity. Each specialist showed a high level of specificity regardless of the diagnostic set. The overall sensitivity of all specialists' assessments was significantly increased by adding RNFLP or the combination of SD-OCT and RNFLP to SH (P < 0.001); however, adding SD-OCT to SH or SHR did not significantly increase the sensitivity. A similar relationship was noted also for the preperimetric glaucoma subgroup.

Conclusions: In contrast to RNFLP, SD-OCT did not significantly enhance the diagnostic accuracy of detecting glaucoma or even of preperimetric glaucoma. Our results suggest that, at least for glaucoma specialists, the additive diagnostic role of OCT is limited.

Original languageEnglish
Pages (from-to)8024-8030
Number of pages7
JournalInvestigative Ophthalmology and Visual Science
Volume55
Issue number12
DOIs
StatePublished - 20 Nov 2014

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Photography
Optical Coherence Tomography
Diagnostic Imaging
Nerve Fibers
Glaucoma
src Homology Domains
Visual Fields

Keywords

  • Additive diagnostic role
  • Glaucoma diagnosis
  • Glaucoma specialist
  • Retinal nerve fiber layer photography
  • Spectral-domain optical coherence tomography

Cite this

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title = "Additive diagnostic role of imaging in glaucoma: Optical coherence tomography and retinal nerve fiber layer photography",
abstract = "Purpose: To investigate the additive diagnostic role of spectral-domain optical coherence tomography (SD-OCT) and red-free retinal nerve fiber layer photography (RNFLP) in making clinical glaucoma diagnosis.Methods: Four diagnostic combination sets, including the most recent image from each measurement of 196 glaucoma eyes (including the 44 preperimetric glaucoma eyes) and 101 healthy eyes, were prepared: (1) stereo disc photography and Humphrey visual field (SH), (2) SH and SD-OCT (SHO), (3) SH and RNFLP (SHR), and (4) SHR and SD-OCT (SHRO). Each randomly sorted set was serially presented at 1-month intervals to five glaucoma specialists who were asked to evaluate them in a subjective and independent manner. The specialists' glaucoma-diagnostic performances based on the sets were then compared.Results: For each specialist, adding SD-OCT to SH or SHR increased the glaucoma-diagnostic sensitivity but not to a level of statistical significance. For one specialist, adding RNFLP to SH significantly increased the sensitivity. Each specialist showed a high level of specificity regardless of the diagnostic set. The overall sensitivity of all specialists' assessments was significantly increased by adding RNFLP or the combination of SD-OCT and RNFLP to SH (P < 0.001); however, adding SD-OCT to SH or SHR did not significantly increase the sensitivity. A similar relationship was noted also for the preperimetric glaucoma subgroup.Conclusions: In contrast to RNFLP, SD-OCT did not significantly enhance the diagnostic accuracy of detecting glaucoma or even of preperimetric glaucoma. Our results suggest that, at least for glaucoma specialists, the additive diagnostic role of OCT is limited.",
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Additive diagnostic role of imaging in glaucoma : Optical coherence tomography and retinal nerve fiber layer photography. / Kim, Ko Eun; Kim, Seok Hwan; Oh, Sohee; Jeoung, Jin Wook; Suh, Min Hee; Seo, Je Hyun; Kim, Martha; Park, Ki Ho; Kim, Dong Myung.

In: Investigative Ophthalmology and Visual Science, Vol. 55, No. 12, 20.11.2014, p. 8024-8030.

Research output: Contribution to journalArticle

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AU - Kim, Ko Eun

AU - Kim, Seok Hwan

AU - Oh, Sohee

AU - Jeoung, Jin Wook

AU - Suh, Min Hee

AU - Seo, Je Hyun

AU - Kim, Martha

AU - Park, Ki Ho

AU - Kim, Dong Myung

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