Activation of the intrinsic coagulation pathway in patients with chronic urticaria

Jung Ah Kim, Sujeoung Kim, Ji Eun Kim, Ja Yoon Gu, Hyun Ju Yoo, Hye Ryun Kang, Hyun Kyung Kim

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Purpose: Although coagulation activation has been reported in chronic urticaria, data pertaining to detailed changes in coagulation factors and global coagulation status are lacking. The current study evaluated global coagulation status in patients with chronic urticaria using thrombin generation assay (TGA) and the levels of individual coagulation factors. Methods: Patients with chronic urticaria (n=57) and 20 healthy controls were enrolled. TGA was performed under stimulation with 2 concentrations of tissue factor (TF). Coagulation factors and conventional coagulation assays were also analyzed. Results: Although patients with chronic urticaria showed prolonged activated partial thromboplastin time, prothrombin time did not differ significantly between patients and controls. In both 1 pM and 5 pM TF-stimulated TGA, peak thrombin and endogenous thrombin potential (ETP) levels were markedly decreased in patients with chronic urticaria. As expected, intrinsic coagulation factors (VIII, IX, and XII), as well as coagulation factors of the common pathway (II, V, and X), were consistently decreased. Additionally, D-dimer was significantly increased in patients as compared to controls. In multivariate regression analysis, the presence of chronic urticaria was the only significant independent contributor to the low ETP value. Conclusions: Chronic urticaria is characterized by in vivo coagulation activation through the intrinsic coagulation pathway, which can be measured with sensitivity using TGA.

Original languageEnglish
Pages (from-to)476-482
Number of pages7
JournalAllergy, Asthma and Immunology Research
Volume7
Issue number5
DOIs
StatePublished - 1 Jan 2015

Fingerprint

Urticaria
Thrombin
Blood Coagulation Factors
Thromboplastin
Factor XII
Intrinsic Factor
Factor IX
Partial Thromboplastin Time
Prothrombin Time
Factor VIII
Multivariate Analysis
Regression Analysis

Keywords

  • Chronic urticaria
  • Coagulation factors
  • Contact pathway
  • Intrinsic coagulation pathway
  • Thrombin generation assay

Cite this

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title = "Activation of the intrinsic coagulation pathway in patients with chronic urticaria",
abstract = "Purpose: Although coagulation activation has been reported in chronic urticaria, data pertaining to detailed changes in coagulation factors and global coagulation status are lacking. The current study evaluated global coagulation status in patients with chronic urticaria using thrombin generation assay (TGA) and the levels of individual coagulation factors. Methods: Patients with chronic urticaria (n=57) and 20 healthy controls were enrolled. TGA was performed under stimulation with 2 concentrations of tissue factor (TF). Coagulation factors and conventional coagulation assays were also analyzed. Results: Although patients with chronic urticaria showed prolonged activated partial thromboplastin time, prothrombin time did not differ significantly between patients and controls. In both 1 pM and 5 pM TF-stimulated TGA, peak thrombin and endogenous thrombin potential (ETP) levels were markedly decreased in patients with chronic urticaria. As expected, intrinsic coagulation factors (VIII, IX, and XII), as well as coagulation factors of the common pathway (II, V, and X), were consistently decreased. Additionally, D-dimer was significantly increased in patients as compared to controls. In multivariate regression analysis, the presence of chronic urticaria was the only significant independent contributor to the low ETP value. Conclusions: Chronic urticaria is characterized by in vivo coagulation activation through the intrinsic coagulation pathway, which can be measured with sensitivity using TGA.",
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Activation of the intrinsic coagulation pathway in patients with chronic urticaria. / Kim, Jung Ah; Kim, Sujeoung; Kim, Ji Eun; Gu, Ja Yoon; Yoo, Hyun Ju; Kang, Hye Ryun; Kim, Hyun Kyung.

In: Allergy, Asthma and Immunology Research, Vol. 7, No. 5, 01.01.2015, p. 476-482.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Activation of the intrinsic coagulation pathway in patients with chronic urticaria

AU - Kim, Jung Ah

AU - Kim, Sujeoung

AU - Kim, Ji Eun

AU - Gu, Ja Yoon

AU - Yoo, Hyun Ju

AU - Kang, Hye Ryun

AU - Kim, Hyun Kyung

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