Acredinones A and B, voltage-dependent potassium channel inhibitors from the sponge-derived fungus Acremonium sp. F9A015

Hiyoung Kim, Inho Yang, Shin Young Ryu, Dong Hwan Won, Awadut G. Giri, Weihong Wang, Hyukjae Choi, Jungwook Chin, Dongyup Hahn, Eunhee Kim, Chulkyeong Han, Jihye Lee, Sang Jip Nam, Won Kyung Ho, Heonjoong Kang

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Abstract

Two new benzophenones, acredinones A (1) and B (2), were isolated from a marine-sponge-associated Acremonium sp. fungus. Their chemical structures were elucidated on the interpretation of spectroscopic data. The structure of 1 was confirmed by palladium-catalyzed hydrogenation, followed by spectroscopic data analysis. Acredinones A (1) and B (2) inhibited the outward K+ currents of the insulin secreting cell line INS-1 with IC50 values of 0.59 and 1.0 μM, respectively.

Original languageEnglish
Pages (from-to)363-367
Number of pages5
JournalJournal of Natural Products
Volume78
Issue number3
DOIs
StatePublished - 27 Mar 2015

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