Abdominal fatness and cerebral white matter hyperintensity

Ki Woong Nam, Hyuktae Kwon, Hyung-Min Kwon, Jin Ho Park, Han Yeong Jeong, Sang Hyuck Kim, Su Min Jeong, Hwa Jung Kim, Seung Sik Hwang

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Although obesity has been proven as a risk factor of metabolic and cardiovascular diseases, there have been few studies addressing the association between obesity and cerebral white matter hyperintensity (WMH) volume with controversial findings. In this study, we evaluated the relationship between abdominal fat distribution and WMH volume in a neurologically healthy population. We performed an observational study in a consecutive series of subjects who were examined during voluntary health check-ups between January 2006 and December 2013. We directly measured both visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) using abdominal computed tomography. The WMH volumes were also recorded quantitatively. A total of 2504 subjects were included in this study. In multivariate analysis, the relationship between SAT and WMH volume remained significant (β = −0.170, standard error [SE] = 0.065, P =.006) after adjusting for confounding factors. The protective effects of SAT on the WMH volume were more prominent in female participants (β = −0.295, SE = 0.138, P =.033) and in severely obese participants (β = −0.358, SE = 0.167, P =.033). Conclusively, we demonstrated a negative association between SAT and WMH volume in a healthy population.

Original languageEnglish
Pages (from-to)52-57
Number of pages6
JournalJournal of the Neurological Sciences
Volume404
DOIs
StatePublished - 15 Sep 2019

Fingerprint

Subcutaneous Fat
Obesity
Abdominal Subcutaneous Fat
Abdominal Fat
Intra-Abdominal Fat
Metabolic Diseases
Population
Observational Studies
White Matter
Cardiovascular Diseases
Multivariate Analysis
Tomography
Health

Keywords

  • Adipose tissue
  • Inflammation
  • Leukoaraiosis
  • Metabolic syndrome
  • Obesity
  • Small vessel disease

Cite this

Nam, Ki Woong ; Kwon, Hyuktae ; Kwon, Hyung-Min ; Park, Jin Ho ; Jeong, Han Yeong ; Kim, Sang Hyuck ; Jeong, Su Min ; Kim, Hwa Jung ; Hwang, Seung Sik. / Abdominal fatness and cerebral white matter hyperintensity. In: Journal of the Neurological Sciences. 2019 ; Vol. 404. pp. 52-57.
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Abdominal fatness and cerebral white matter hyperintensity. / Nam, Ki Woong; Kwon, Hyuktae; Kwon, Hyung-Min; Park, Jin Ho; Jeong, Han Yeong; Kim, Sang Hyuck; Jeong, Su Min; Kim, Hwa Jung; Hwang, Seung Sik.

In: Journal of the Neurological Sciences, Vol. 404, 15.09.2019, p. 52-57.

Research output: Contribution to journalArticleResearchpeer-review

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