A two-photon fluorescent probe for amyloid-β plaques in living mice

Cheol Ho Heo, Kyung Ho Kim, Hyung Joong Kim, Sung Hoon Baik, Hyundong Song, Yong Soo Kim, Jeewoo Lee, Inhee Mook-Jung, Hwan Myung Kim

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

We report a small molecule two-photon probe (SAD1) that shows a significant TP action cross section (170 GM), binds to Aβ plaques specifically, readily enters the brain through the BBB, and can directly 3D monitor the individual Aβ plaque in living transgenic mice at more than 380 μm depths.

Original languageEnglish
Pages (from-to)1303-1305
Number of pages3
JournalChemical Communications
Volume49
Issue number13
DOIs
StatePublished - 17 Jan 2013

Cite this

Heo, C. H., Kim, K. H., Kim, H. J., Baik, S. H., Song, H., Kim, Y. S., Lee, J., Mook-Jung, I., & Kim, H. M. (2013). A two-photon fluorescent probe for amyloid-β plaques in living mice. Chemical Communications, 49(13), 1303-1305. https://doi.org/10.1039/c2cc38570h