A randomized, double-blind, placebo-controlled trial of vitamin C iontophoresis in melasma

Chang Hun Huh, Koo Il Seo, Je Young Park, Jeong Gu Lim, Hee Chul Eun, Kyung Chan Park

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Background: Vitamin C is known to both inhibit melanin formation and reduce oxidized melanin. However, vitamin C does not easily penetrate the skin. In this study, vitamin C iontophoresis was employed in order to enhance vitamin C penetration. Objective: The purpose of this study was to evaluate the efficacy of vitamin C iontophoresis for melasma patients. Methods: Twenty-nine females with melasma were enrolled. For iontophoresis, a vitamin C solution was applied to one side of the face, while distilled water was applied to the other side as a control. The L (luminance) value was measured by a colorimeter to obtain an objective pigmentation parameter. Results: Twelve weeks after iontophoresis, the colorimeter of the treated site showed a significant decrease in the L value (from 4.60 to 2.78, p = 0.002), compared to that of the control site (from 4.45 to 3.87, p = 0.142). Conclusion: Vitamin C iontophoresis may be an effective treatment modality for melasma.

Original languageEnglish
Pages (from-to)316-320
Number of pages5
JournalDermatology
Volume206
Issue number4
DOIs
StatePublished - 17 Jun 2003

Fingerprint

Melanosis
Iontophoresis
Ascorbic Acid
Placebos
Melanins
Pigmentation
Skin
Water

Keywords

  • Ascorbic acid
  • Chloasma
  • Iontophoresis
  • Magnesium-L-ascorbyl-2-phosphate
  • Melasma
  • Vitamin C

Cite this

Huh, Chang Hun ; Seo, Koo Il ; Park, Je Young ; Lim, Jeong Gu ; Eun, Hee Chul ; Park, Kyung Chan. / A randomized, double-blind, placebo-controlled trial of vitamin C iontophoresis in melasma. In: Dermatology. 2003 ; Vol. 206, No. 4. pp. 316-320.
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A randomized, double-blind, placebo-controlled trial of vitamin C iontophoresis in melasma. / Huh, Chang Hun; Seo, Koo Il; Park, Je Young; Lim, Jeong Gu; Eun, Hee Chul; Park, Kyung Chan.

In: Dermatology, Vol. 206, No. 4, 17.06.2003, p. 316-320.

Research output: Contribution to journalArticle

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AU - Park, Kyung Chan

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