A network perspective on unraveling the role of TRP channels in biology and disease

Jung Nyeo Chun, Jin Muk Lim, Young Kang, Eung Hee Kim, Young Cheul Shin, Hong Gee Kim, Dayk Jang, Dongseop Kwon, Soo Yong Shin, Insuk So, Ju-Hong Jeon

Research output: Contribution to journalReview articleResearchpeer-review

12 Citations (Scopus)

Abstract

Transient receptor potential (TRP) channels are a large family of non-selective cation channels that mediate numerous physiological and pathophysiological processes; however, still largely unknown are the underlying molecular mechanisms. With data generated on an unprecedented scale, network-based approaches have been revolutionizing the way in which we understand biology and disease, discover disease genes, and develop therapeutic strategies. These circumstances have created opportunities to encounter TRP channel research to data-intensive science. In this review, we provide an introduction of network-based approaches in biomedical science, describe the current state of TRP channel network biology, and discuss the future direction of TRP channel research. Network perspective will facilitate the discovery of latent roles and underlying mechanisms of TRP channels in biology and disease.

Original languageEnglish
Pages (from-to)173-182
Number of pages10
JournalPflugers Archiv European Journal of Physiology
Volume466
Issue number2
DOIs
StatePublished - 1 Feb 2014

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Transient Receptor Potential Channels
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Keywords

  • Data-driven science
  • Network
  • Protein-protein interaction
  • TRP channel

Cite this

Chun, Jung Nyeo ; Lim, Jin Muk ; Kang, Young ; Kim, Eung Hee ; Shin, Young Cheul ; Kim, Hong Gee ; Jang, Dayk ; Kwon, Dongseop ; Shin, Soo Yong ; So, Insuk ; Jeon, Ju-Hong. / A network perspective on unraveling the role of TRP channels in biology and disease. In: Pflugers Archiv European Journal of Physiology. 2014 ; Vol. 466, No. 2. pp. 173-182.
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abstract = "Transient receptor potential (TRP) channels are a large family of non-selective cation channels that mediate numerous physiological and pathophysiological processes; however, still largely unknown are the underlying molecular mechanisms. With data generated on an unprecedented scale, network-based approaches have been revolutionizing the way in which we understand biology and disease, discover disease genes, and develop therapeutic strategies. These circumstances have created opportunities to encounter TRP channel research to data-intensive science. In this review, we provide an introduction of network-based approaches in biomedical science, describe the current state of TRP channel network biology, and discuss the future direction of TRP channel research. Network perspective will facilitate the discovery of latent roles and underlying mechanisms of TRP channels in biology and disease.",
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A network perspective on unraveling the role of TRP channels in biology and disease. / Chun, Jung Nyeo; Lim, Jin Muk; Kang, Young; Kim, Eung Hee; Shin, Young Cheul; Kim, Hong Gee; Jang, Dayk; Kwon, Dongseop; Shin, Soo Yong; So, Insuk; Jeon, Ju-Hong.

In: Pflugers Archiv European Journal of Physiology, Vol. 466, No. 2, 01.02.2014, p. 173-182.

Research output: Contribution to journalReview articleResearchpeer-review

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T1 - A network perspective on unraveling the role of TRP channels in biology and disease

AU - Chun, Jung Nyeo

AU - Lim, Jin Muk

AU - Kang, Young

AU - Kim, Eung Hee

AU - Shin, Young Cheul

AU - Kim, Hong Gee

AU - Jang, Dayk

AU - Kwon, Dongseop

AU - Shin, Soo Yong

AU - So, Insuk

AU - Jeon, Ju-Hong

PY - 2014/2/1

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AB - Transient receptor potential (TRP) channels are a large family of non-selective cation channels that mediate numerous physiological and pathophysiological processes; however, still largely unknown are the underlying molecular mechanisms. With data generated on an unprecedented scale, network-based approaches have been revolutionizing the way in which we understand biology and disease, discover disease genes, and develop therapeutic strategies. These circumstances have created opportunities to encounter TRP channel research to data-intensive science. In this review, we provide an introduction of network-based approaches in biomedical science, describe the current state of TRP channel network biology, and discuss the future direction of TRP channel research. Network perspective will facilitate the discovery of latent roles and underlying mechanisms of TRP channels in biology and disease.

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