A genome-wide by PM10 interaction study identifies novel loci for lung function near BICD1 and IL1RN-IL1F10 genes in Korean adults

Hyun Jin Kim, Yong Seok Seo, Joohon Sung, Jeesoo Chae, Jae Moon Yun, Hyuktae Kwon, Belong Cho, Jong Il Kim, Jin Ho Park

Research output: Contribution to journalArticle

Abstract

Although several genome-wide interaction studies (GWIS) have been performed in specific European populations to understand the missing link between genetic and environmental factors for lung function, GWIS of Asian samples remain rare. Therefore, we performed a GWIS of exposure to air pollution to identify loci for lung function in Korean adult men. A total of 1826 adult men recruited from two health check-up centers were included in the analysis and the annual mean concentrations of ambient particulate matter with an aerodynamic diameter ≤10 μm (PM10) were used. In case of forced vital capacity (FVC), one SNP (rs12312730) that passed our genome-wide threshold of pint < 1 × 10–5 was detected in the intronic region of the BICD1 gene on chromosome 12. In addition, we found two variants (rs6743376 and rs17042888) located near the IL1RN-IL1F10 gene that were involved in the inflammatory response and associated with decreased FVC via interaction with PM10 exposure. A stratified association analysis according to these SNP genotypes showed that PM10 concentrations in subjects with one or two of the risk alleles, compared with those with the non-risk allele, were significantly correlated with a reduction in FVC. This pattern was replicated in another 892 Korean adult samples. The current study reports the first GWIS discovery in an Asian population: the BICD1 and IL1RN-IL1F10 genes may contribute to the decrease in FVC levels by interacting with PM10 exposure.

Original languageEnglish
Article number125581
JournalChemosphere
Volume245
DOIs
StatePublished - Apr 2020

Fingerprint

Vital Capacity
genome
Genes
Genome
Lung
gene
Single Nucleotide Polymorphism
allele
Alleles
Chromosomes, Human, Pair 12
Particulate Matter
Air Pollution
Population
aerodynamics
particulate matter
chromosome
genotype
environmental factor
atmospheric pollution
Genotype

Keywords

  • Genome-wide interaction
  • Korean men
  • Lung function
  • Particulate matter

Cite this

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title = "A genome-wide by PM10 interaction study identifies novel loci for lung function near BICD1 and IL1RN-IL1F10 genes in Korean adults",
abstract = "Although several genome-wide interaction studies (GWIS) have been performed in specific European populations to understand the missing link between genetic and environmental factors for lung function, GWIS of Asian samples remain rare. Therefore, we performed a GWIS of exposure to air pollution to identify loci for lung function in Korean adult men. A total of 1826 adult men recruited from two health check-up centers were included in the analysis and the annual mean concentrations of ambient particulate matter with an aerodynamic diameter ≤10 μm (PM10) were used. In case of forced vital capacity (FVC), one SNP (rs12312730) that passed our genome-wide threshold of pint < 1 × 10–5 was detected in the intronic region of the BICD1 gene on chromosome 12. In addition, we found two variants (rs6743376 and rs17042888) located near the IL1RN-IL1F10 gene that were involved in the inflammatory response and associated with decreased FVC via interaction with PM10 exposure. A stratified association analysis according to these SNP genotypes showed that PM10 concentrations in subjects with one or two of the risk alleles, compared with those with the non-risk allele, were significantly correlated with a reduction in FVC. This pattern was replicated in another 892 Korean adult samples. The current study reports the first GWIS discovery in an Asian population: the BICD1 and IL1RN-IL1F10 genes may contribute to the decrease in FVC levels by interacting with PM10 exposure.",
keywords = "Genome-wide interaction, Korean men, Lung function, Particulate matter",
author = "Kim, {Hyun Jin} and Seo, {Yong Seok} and Joohon Sung and Jeesoo Chae and Yun, {Jae Moon} and Hyuktae Kwon and Belong Cho and Kim, {Jong Il} and Park, {Jin Ho}",
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A genome-wide by PM10 interaction study identifies novel loci for lung function near BICD1 and IL1RN-IL1F10 genes in Korean adults. / Kim, Hyun Jin; Seo, Yong Seok; Sung, Joohon; Chae, Jeesoo; Yun, Jae Moon; Kwon, Hyuktae; Cho, Belong; Kim, Jong Il; Park, Jin Ho.

In: Chemosphere, Vol. 245, 125581, 04.2020.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A genome-wide by PM10 interaction study identifies novel loci for lung function near BICD1 and IL1RN-IL1F10 genes in Korean adults

AU - Kim, Hyun Jin

AU - Seo, Yong Seok

AU - Sung, Joohon

AU - Chae, Jeesoo

AU - Yun, Jae Moon

AU - Kwon, Hyuktae

AU - Cho, Belong

AU - Kim, Jong Il

AU - Park, Jin Ho

PY - 2020/4

Y1 - 2020/4

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AB - Although several genome-wide interaction studies (GWIS) have been performed in specific European populations to understand the missing link between genetic and environmental factors for lung function, GWIS of Asian samples remain rare. Therefore, we performed a GWIS of exposure to air pollution to identify loci for lung function in Korean adult men. A total of 1826 adult men recruited from two health check-up centers were included in the analysis and the annual mean concentrations of ambient particulate matter with an aerodynamic diameter ≤10 μm (PM10) were used. In case of forced vital capacity (FVC), one SNP (rs12312730) that passed our genome-wide threshold of pint < 1 × 10–5 was detected in the intronic region of the BICD1 gene on chromosome 12. In addition, we found two variants (rs6743376 and rs17042888) located near the IL1RN-IL1F10 gene that were involved in the inflammatory response and associated with decreased FVC via interaction with PM10 exposure. A stratified association analysis according to these SNP genotypes showed that PM10 concentrations in subjects with one or two of the risk alleles, compared with those with the non-risk allele, were significantly correlated with a reduction in FVC. This pattern was replicated in another 892 Korean adult samples. The current study reports the first GWIS discovery in an Asian population: the BICD1 and IL1RN-IL1F10 genes may contribute to the decrease in FVC levels by interacting with PM10 exposure.

KW - Genome-wide interaction

KW - Korean men

KW - Lung function

KW - Particulate matter

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JF - Chemosphere

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