A case of renal crisis in a Korean scleroderma patient with anti-RNA polymerase I and III antibodies

Ha Kang Eun, Hyun Im Churl, Ho Kim Su, Rak Chung Jae, Young Lee Eun, Jo Kim Dong, Bong Lee Eun, Wook Song Yeong

Research output: Contribution to journalArticle

Abstract

Scleroderma (SSc) renal crisis has been reported to be associated with anti-RNA polymerase I and III (RNAP I/III) antibodies in Caucasians and the Japanese. However, no report is available for Korean SSc patients. Here, we describe the case of a 65-yr-old female SSc patient who developed renal crisis and whose serum contained anti-RNAP I/III antibodies. She was finally diagnosed as having diffuse cutaneous SSc based on skin thickening proximal to the elbows and knees. Sudden hypertension, oliguria, and pulmonary edema were features of her renal crisis. Despite the use of captopril and adequate blood pressure control, her renal function deteriorated. Subsequent renal biopsy findings showed severe fibrinoid necrosis with luminal obliteration in interlobar arteries and arterioles consistent with SSc renal crisis. Serum anti-RNAP I/III antibodies were detected by radioimmunoprecipitation. This is the first report of a renal crisis in a Korean SSc patient with RNAP I/III antibodies.

Original languageEnglish
Pages (from-to)1121-1123
Number of pages3
JournalJournal of Korean Medical Science
Volume21
Issue number6
StatePublished - 1 Dec 2006

Keywords

  • Autoantibodies
  • RNA polymerase I
  • RNA polymerase III
  • Scleroderma, systemic

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