A case of MOG encephalomyelitis with T- cell lymphoma

Young Nam Kwon, Jiwon Koh, Yoon Kyung Jeon, Jung Joon Sung, Sung Hye Park, Sung Min Kim

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Background: Myelin oligodendrocyte glycoprotein immunoglobulin-G (IgG)-associated encephalomyelitis (MOG-EM) is a distinct inflammatory demyelinating disease. We present an unusual MOG-EM cases with concomitant T-cell lymphoma. Case report: A 38-year-old Caucasian male presented with bilateral optic neuritis and multifocal transverse myelitis. He tested positive for MOG-IgG1 and his neurologic symptoms improved with high dose steroid treatment. Six months after his first MOG-EM symptoms, he developed ulcerative skin lesions on his leg and was diagnosed with primary cutaneous γδ T-cell lymphoma. The immunohistochemistry study, performed on his cancer tissue, was negative for MOG. Conclusion: Diagnosis of MOG-EM can be considered in patients with concomitant hematologic malignancy, which might be associated with the dysregulated adaptive immunity rather than the direct presentation of the onconeural antigen by cancer. Further studies need to be conducted for the risks and incidence of malignancy in a larger cohort of MOG-EM.

Original languageEnglish
Article number102038
JournalMultiple Sclerosis and Related Disorders
StatePublished - Jun 2020



  • Cancer
  • Concomitant
  • MOG
  • Malignancy
  • Myelin oligodendrocyte glycoprotein encephalomyelitis

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