A Case of hereditary spherocytosis coexisting with Gilbert's syndrome

Min J.ae Lee, Yoon Hwan Chang, Seung H.wa Kang, Se K.won Mun, Heyjin Kim, Chul J.u. Han, Jin Kim, Hye J.in Kang

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4 Citations (Scopus)

Abstract

We recently encountered a case of hereditary spherocytosis coexisting with Gilbert's syndrome. Patient was initially diagnosed with Gilbert's syndrome and observed, but other findings suggestive of concurrent hemolysis, such as splenomegaly and gallstones were noted during the follow-up period. Therefore, further evaluations, including a peripheral blood smear, osmotic fragility test, autohemolysis test, and red blood cell membrane protein test were performed, and coexisting hereditary spherocytosis was diagnosed. Genotyping of the conjugation enzyme uridine diphosphate-glucuronosyltransferase was used to confirm Gilbert's syndrome. Because of the high prevalence rates and similar symptoms of these 2 diseases, hereditary spherocytosis can be masked in patients with Gilbert's syndrome. In review of a case and other article, the possibility of the coexistence of these 2 diseases should be considered, especially in patients with unconjugated hyperbilirubinemia who also have splenomegaly and gallstones.

Original languageEnglish
Pages (from-to)166-169
Number of pages4
JournalThe Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
Volume61
Issue number3
StatePublished - 25 Mar 2013
Externally publishedYes

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Gilbert Disease
Hereditary Spherocytosis
Splenomegaly
Gallstones
Osmotic Fragility
Glucuronosyltransferase
Uridine Diphosphate
Hyperbilirubinemia
Hemolysis
Membrane Proteins
Erythrocytes
Enzymes

Cite this

Lee, M. J. A., Chang, Y. H., Kang, S. H. W., Mun, S. K. W., Kim, H., Han, C. J. U., ... Kang, H. J. I. (2013). A Case of hereditary spherocytosis coexisting with Gilbert's syndrome. The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, 61(3), 166-169.
Lee, Min J.ae ; Chang, Yoon Hwan ; Kang, Seung H.wa ; Mun, Se K.won ; Kim, Heyjin ; Han, Chul J.u. ; Kim, Jin ; Kang, Hye J.in. / A Case of hereditary spherocytosis coexisting with Gilbert's syndrome. In: The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi. 2013 ; Vol. 61, No. 3. pp. 166-169.
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Lee, MJA, Chang, YH, Kang, SHW, Mun, SKW, Kim, H, Han, CJU, Kim, J & Kang, HJI 2013, 'A Case of hereditary spherocytosis coexisting with Gilbert's syndrome', The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, vol. 61, no. 3, pp. 166-169.

A Case of hereditary spherocytosis coexisting with Gilbert's syndrome. / Lee, Min J.ae; Chang, Yoon Hwan; Kang, Seung H.wa; Mun, Se K.won; Kim, Heyjin; Han, Chul J.u.; Kim, Jin; Kang, Hye J.in.

In: The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, Vol. 61, No. 3, 25.03.2013, p. 166-169.

Research output: Contribution to journalArticleResearchpeer-review

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